METHOD FOR SCREENING SUBSTANCE SUPPRESSING PARAKERATOSIS, SUBSTANCE SCREENED BY THE SAME METHOD AND METHOD FOR SUPPRESSING PARAKERATOSIS

PROBLEM TO BE SOLVED: To develop a means for suppressing/treating epidermal parakeratosis with an entirely new approach as opposed to the conventional technology by elucidating the mechanism of the epidermal parakeratosis. SOLUTION: The activity of a cadet substance suppressing a cysteine protease i...

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Hauptverfasser: KATAGIRI CHIKA, HIBINO TOSHIHIKO, NAKANISHI JIYOUTAROU
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HIBINO TOSHIHIKO
NAKANISHI JIYOUTAROU
description PROBLEM TO BE SOLVED: To develop a means for suppressing/treating epidermal parakeratosis with an entirely new approach as opposed to the conventional technology by elucidating the mechanism of the epidermal parakeratosis. SOLUTION: The activity of a cadet substance suppressing a cysteine protease inhibitory activity possessed by SCCA-1 (squamous cell carcinoma antigen type 1) is used as an index. A method for screening the substance suppressing the epidermal parakeratosis, the substance suppressing the epidermal parakeratosis screened by the method and a method for suppressing a caspase-14 inhibitory activity of the SCCA-1 in epidermal cells, thereby normalizing the keratinization of the epidermal cells and suppressing the epidermal parakeratosis are provided. COPYRIGHT: (C)2006,JPO&NCIPI
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
TESTING
VINEGAR
WINE
title METHOD FOR SCREENING SUBSTANCE SUPPRESSING PARAKERATOSIS, SUBSTANCE SCREENED BY THE SAME METHOD AND METHOD FOR SUPPRESSING PARAKERATOSIS
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