METHOD FOR SCREENING SUBSTANCE SUPPRESSING PARAKERATOSIS, SUBSTANCE SCREENED BY THE SAME METHOD AND METHOD FOR SUPPRESSING PARAKERATOSIS

PROBLEM TO BE SOLVED: To develop a means for suppressing/treating epidermal parakeratosis with an entirely new approach as opposed to the conventional technology by elucidating the mechanism of the epidermal parakeratosis. SOLUTION: The activity of a cadet substance suppressing a cysteine protease i...

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Bibliographische Detailangaben
Hauptverfasser:	KATAGIRI CHIKA, HIBINO TOSHIHIKO, NAKANISHI JIYOUTAROU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PROBLEM TO BE SOLVED: To develop a means for suppressing/treating epidermal parakeratosis with an entirely new approach as opposed to the conventional technology by elucidating the mechanism of the epidermal parakeratosis. SOLUTION: The activity of a cadet substance suppressing a cysteine protease inhibitory activity possessed by SCCA-1 (squamous cell carcinoma antigen type 1) is used as an index. A method for screening the substance suppressing the epidermal parakeratosis, the substance suppressing the epidermal parakeratosis screened by the method and a method for suppressing a caspase-14 inhibitory activity of the SCCA-1 in epidermal cells, thereby normalizing the keratinization of the epidermal cells and suppressing the epidermal parakeratosis are provided. COPYRIGHT: (C)2006,JPO&NCIPI