SULFONATED AMINO ACID DERIVATIVE AND METALLOPROTEINASE INHIBITOR CONTAINING THE SAME

SULFONATED AMINO ACID DERIVATIVE AND METALLOPROTEINASE INHIBITOR CONTAINING THE SAME

PROBLEM TO BE SOLVED: To provide a sulfonated amino acid derivative, and to provide a metalloproteinase inhibitor containing the same. SOLUTION: The sulfonated amino acid derivative is a compound of the formula(I)[ wherein, R1is e.g. a (substituted) lower alkyl; R2is H; R3is a single bond; R4is a si...

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Hauptverfasser: OTANI MITSUAKI, WATANABE FUMIHIKO, TSUZUKI HIROSHIGE
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a sulfonated amino acid derivative, and to provide a metalloproteinase inhibitor containing the same. SOLUTION: The sulfonated amino acid derivative is a compound of the formula(I)[ wherein, R1is e.g. a (substituted) lower alkyl; R2is H; R3is a single bond; R4is a single bond; R5is a (substituted) lower alkyl; and Y is NHOH or OH ], an optical active substance thereof, or a pharmaceutically acceptable salt thereof, or hydrate thereof, having metalloproteinase inhibitory activity. COPYRIGHT: (C)2006,JPO&NCIPI