MODIFIED HEMOGLOBIN COMPOUND AND METHOD FOR REFINING THE SAME

PROBLEM TO BE SOLVED: To provide a modified hemoglobin-like compound having desired characteristics, and to provide a simple method for giving a specific molecular weight distribution in a high-molecular weight hemoglobin mixture. SOLUTION: The modified hemoglobin-like compound is provided, in one a...

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Hauptverfasser: MARQUARDT DAVID A, TRIMBLE STEPHEN P, MATHEWS ANTONY J, EPP JANET K, ANTHONY-CAHILL SPENCER, KERWIN BRUCE A, MADRIL DOMINIC G, ANDERSON DAVID C
Format: Patent
Sprache:eng
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a modified hemoglobin-like compound having desired characteristics, and to provide a simple method for giving a specific molecular weight distribution in a high-molecular weight hemoglobin mixture. SOLUTION: The modified hemoglobin-like compound is provided, in one aspect, being a globulin-like polypeptide having multiple dialpha domains. Such a polypeptide contains two or more dialpha domains, so-called "di-dialpha" domains, which are mutually joined via peptide linkers each having at least five amino acids, preferably at least seven amino acids, wherein the linker is encoded preferably by a peptide linker having Ser-Gly-Gly as recurring unit. COPYRIGHT: (C)2006,JPO&NCIPI