LAMININ BINDING-TYPE alpha-DG SYNTHESIS ACCELERATING AGENT

PROBLEM TO BE SOLVED: To provide a use of LARGE 2 as a laminin binding-type α-dystroglycan synthesis accelerating factor. SOLUTION: A laminin binding-type α-dystroglycan synthesis accelerating agent contains a polypeptide comprising (a) a polypeptide which comprises a specified amino acid sequence o...

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Hauptverfasser:	HIRUMA TORU, SAKAI TOKIKO, OKURA TAKASHI, FUJIMURA KATSUYA, NARIMATSU HISASHI, SAWAKI HIROMICHI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a use of LARGE 2 as a laminin binding-type α-dystroglycan synthesis accelerating factor. SOLUTION: A laminin binding-type α-dystroglycan synthesis accelerating agent contains a polypeptide comprising (a) a polypeptide which comprises a specified amino acid sequence or (b) a polypeptide which comprises an amino acid sequence given by subjecting one or several amino acids in the specified amino acid sequence to deletion, substitution, or addition and induces glycosylation of α-dystroglycan and/or extracellular secretion of laminin binding-type α-dystroglycan by being introduced into a cell. The laminin binding-type α-dystroglycan synthesis accelerating agent containing the factor and a pharmaceutical composition are provided, respectively. COPYRIGHT: (C)2006,JPO&NCIPI