ARIPIPRAZOLE ANHYDRIDE CRYSTALS, METHODS FOR PRODUCING THEM AND PREPARATIONS CONTAINING THEM

PROBLEM TO BE SOLVED: To provide aripiprazole anhydride crystals which hardly change, even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for a long period, and do substantially deteriorate their solubility. SOLUTION: The aripiprazole anhydride crystals have th...

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Hauptverfasser:	OI SACHIHIRO, YAMADA SHOHEI, TAKAHASHI MASANORI, TOMINAGA MICHIAKI, NIIHAMA KOICHI, NISHIOKA YOSHIHIRO, TANIGUCHI YOICHI, YABUUCHI TAKESHI, NAKAGAWA TOMONORI, KAWASAKI JUNICHI, FUJIMOTO SEI, KOBAYASHI ISAYUKI, TOMIKAWA KENJI, ISHIGAMI MAKOTO, ABE KAORU, BANDO TAKUJI, AOKI SATOYUKI, UTSUMI NAOTO, FUJIMURA TSUTOMU
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Zusammenfassung:	PROBLEM TO BE SOLVED: To provide aripiprazole anhydride crystals which hardly change, even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for a long period, and do substantially deteriorate their solubility. SOLUTION: The aripiprazole anhydride crystals have the same1H-NMR spectrum as1H-NMR spectrum shown in Fig 9, the same powder X-ray diffraction spectrum as powder X-ray diffraction spectrum shown in Fig 10, and the same IR spectrum as an IR (KBr) spectrum shown in Fig 11. The aripiprazole anhydride crystals have low hygroscopic, and hardly change, even when stored for a long period. COPYRIGHT: (C)2006,JPO&NCIPI