METHODS FOR TREATING BIOLOGICAL TISSUE TO MITIGATE CALCIFICATION

PROBLEM TO BE SOLVED: To provide a method for treating fixed biological tissue which inhibits calcification of the biological tissue following implantation thereof in a mammalian body. SOLUTION: The method includes a process for placing the biological tissue in contact with a treatment solution, a process for inducing relative tissue/solution movement, and a process for heating the treatment solution. The relative movement may be induced by shaking a container in which the tissue is immersed in the treatment solution, or by stirring the solution within the container. The movement may also be induced by making the treatment solution flow through the tissue to be treated. The tissue may be free to move in the treatment container, or may be restrained from moving largely. The flow may be part of a circulation system having a reservoir, with a heater being provided to heat the treatment solution in the reservoir. COPYRIGHT: (C)2006,JPO&NCIPI