ESTER COMPOUND AND PHARMACEUTICAL USE OF THE SAME

PROBLEM TO BE SOLVED: To provide a hyperlipemia treating agent capable of inhibiting selectively a microsomal triglyceride transfer protein (MTP) in the small bowel, without acting substantially on the MTP in the liver, nor producing an adverse effect, such as fatty liver. SOLUTION: An ester compound expressed by general formula (1') [R2', R2"are each H, a 1-6C (halo)alkyl, a 1-6C alkoxy, a 1-6C acyl, a 3-7C cycloalkyl, a halogen, a 2-6C alkenyl or cyano; X1is -O- or NR10-(R10is H, a 1-6C alkyl or a 3-7C cycloalkyl); R1, R3, R4, R5, R6, R7, R8, R9, ring C, l and m are each defined in the specification, provided that a case in which ring C is a 6-14C aryl, a heterocyclic or a 3-7C cycloaryl, and R8and R9are each -CON(R18)(R19) (R18and R19are each defined in the specification) or -COO(R20) (R20is defined in the specification) is not included] or its pharmaceutically acceptable salt is provided. COPYRIGHT: (C)2005,JPO&NCIPI