UTILIZATION OF ANTI-HLA-DR ANTIBODY

PROBLEM TO BE SOLVED: To provide an anti-HLA (human leucocyte antigen)-DR monoclonal antibody. SOLUTION: An HLA-DR-bonding antibody having the properties: (a) it exhibits an effect of prolonging the life of a non-human animal carrying HLA-DR producing cancerous cells and (b) its suppressive activity...

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Hauptverfasser:	TAWARA TOMONORI, KATAOKA YUKIRO
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide an anti-HLA (human leucocyte antigen)-DR monoclonal antibody. SOLUTION: An HLA-DR-bonding antibody having the properties: (a) it exhibits an effect of prolonging the life of a non-human animal carrying HLA-DR producing cancerous cells and (b) its suppressive activity against an immunoreaction is weaker than L243 or a functional fragment thereof is provided. Alternatively, an HLA-DR-bonding antibody that exhibits an immunosuppressive activity equivalent to a mouse anti-HLA-DR monoclonal antibody L243 (ATCC HB-55) or stronger than L243 or a functional fragment thereof is provided. COPYRIGHT: (C)2005,JPO&NCIPI