SYNTHESIS OF 3, 6-DIALKYL-5, 6-DIHYDRO-4-HYDROXY-2H-PYRAN-2-YL

PROBLEM TO BE SOLVED: To provide a method for hydrogenation of a β-keto carboxylic acid ester which is a material for an enantioselective synthesis of a δ-lactone useful as a precursor for orlistat. SOLUTION: The process comprises hydrogenation of the β-ketoester represented by chemical formula (1)...

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Bibliographische Detailangaben
Hauptverfasser:	SCALONE MICHELANGELO, HODGES LEWIS M, HARRINGTON PETER JOHN, PUENTENER KURT
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM APPARATUS THEREFOR CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY CHEMISTRY GENERAL METHODS OF ORGANIC CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL THEIR RELEVANT APPARATUS TRANSPORTING
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for hydrogenation of a β-keto carboxylic acid ester which is a material for an enantioselective synthesis of a δ-lactone useful as a precursor for orlistat. SOLUTION: The process comprises hydrogenation of the β-ketoester represented by chemical formula (1) in the presence of hydrogen gas of