ITRACONAZOLE PREPARATION FOR ORAL ADMINISTRATION

PROBLEM TO BE SOLVED: To develop itraconazole preparation having high bioavailability and develop a method for efficiently and inexpensively producing the preparation. SOLUTION: Itraconazole fine granules for oral administration improved in bioavailability are obtained by absorbing itraconazole into...

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Hauptverfasser: HAMASHIMA HIROSHI, KANAYAMA YOSHINARI
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creator HAMASHIMA HIROSHI
KANAYAMA YOSHINARI
description PROBLEM TO BE SOLVED: To develop itraconazole preparation having high bioavailability and develop a method for efficiently and inexpensively producing the preparation. SOLUTION: Itraconazole fine granules for oral administration improved in bioavailability are obtained by absorbing itraconazole into a core substance composed of silicic acid or its salt or coating the core substance with itraconazole by a method for spraying an itraconazole solution obtained by dissolving itraconazole into methylene chloride to the core substance and drying the solution, a method, etc., for melting the itraconazole. Granules, tablets and capsules are each produced from the fine granules. COPYRIGHT: (C)2004,JPO&NCIPI
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ITRACONAZOLE PREPARATION FOR ORAL ADMINISTRATION
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