ITRACONAZOLE PREPARATION FOR ORAL ADMINISTRATION
PROBLEM TO BE SOLVED: To develop itraconazole preparation having high bioavailability and develop a method for efficiently and inexpensively producing the preparation. SOLUTION: Itraconazole fine granules for oral administration improved in bioavailability are obtained by absorbing itraconazole into...
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creator | HAMASHIMA HIROSHI KANAYAMA YOSHINARI |
description | PROBLEM TO BE SOLVED: To develop itraconazole preparation having high bioavailability and develop a method for efficiently and inexpensively producing the preparation. SOLUTION: Itraconazole fine granules for oral administration improved in bioavailability are obtained by absorbing itraconazole into a core substance composed of silicic acid or its salt or coating the core substance with itraconazole by a method for spraying an itraconazole solution obtained by dissolving itraconazole into methylene chloride to the core substance and drying the solution, a method, etc., for melting the itraconazole. Granules, tablets and capsules are each produced from the fine granules. COPYRIGHT: (C)2004,JPO&NCIPI |
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SOLUTION: Itraconazole fine granules for oral administration improved in bioavailability are obtained by absorbing itraconazole into a core substance composed of silicic acid or its salt or coating the core substance with itraconazole by a method for spraying an itraconazole solution obtained by dissolving itraconazole into methylene chloride to the core substance and drying the solution, a method, etc., for melting the itraconazole. Granules, tablets and capsules are each produced from the fine granules. 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subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | ITRACONAZOLE PREPARATION FOR ORAL ADMINISTRATION |
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