DEXTROROTATORY GLUCOSE LIPID A ANALOG

PROBLEM TO BE SOLVED: To provide a dextrorotatory glucose lipid A analog that has excellent macrophage activity-inhibitory action and is useful as an antiinflammatory agent, an anti-autoimmune disease agent, an immunosuppressive agent, a prognosis-improving agent after coronary artery bypass grafting or an antisepticemic agent. SOLUTION: This medicinal composition contains a compound represented by general formula [wherein Q is O atom, a 1-3C alkylene, a group of -O-Alk- or a group of -O-Alk-O- (Alk is a 1-3C alkylene) R1, R2and R4are each identical or different, H, a 1-20C alkyl which may be substituted, a 2-20C alkenyl which may be substituted, a 2-20C alkynyl which may be substituted, a 1-20C alkanoyl which may be substituted, a 3-20C alkenoyl which may be substituted or a 3-20C alkynoyl which may be substituted; R3is an 1-20C alkanoyl which may be substituted, a 3-20C alkenoyl which may be substituted, a 3-20C alkynoyl which may be substituted; R5is H, a halogen atom, hydroxy, a 1-6C alkoxy which may be substituted, a 2-6C alkenyloxy which may be substituted or a 2-6C alkynyloxy which may be substituted] or their pharmacologically acceptable salts as an active ingredient. COPYRIGHT: (C)2004,JPO&NCIPI