MODIFIED FACTOR VIII cDNA AND ITS DERIVATIVE

PROBLEM TO BE SOLVED: To provide a modified human factor VIII cDNA. SOLUTION: This cDNA is a modified human factor VIII cDNA wherein mutations are inserted either in the wild-type factor VIII cDNA or in a factor VIII cDNA in which the B-domain is partially or completely deleted and replaced with a D...

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Bibliographische Detailangaben
Hauptverfasser:	WEIMER THOMAS, PHILLIPS MARTIN, HAUSER HANS-PETER DR
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a modified human factor VIII cDNA. SOLUTION: This cDNA is a modified human factor VIII cDNA wherein mutations are inserted either in the wild-type factor VIII cDNA or in a factor VIII cDNA in which the B-domain is partially or completely deleted and replaced with a DNA linker segment, and (A) one or several codons of the human factor VIII cDNA which are not identical with the corresponding codon in the same position of the porcine factor VIII cDNA are substituted by a different codon in such a way that, when the human sequence contains a codon for a neutral amino acid whereas the porcine sequence contains a codon for a charged amino acid, a codon concerning the charged amino acid is introduced into the human sequence; whereas, when the porcine sequence contains a codon for a neutral amino acid, a codon for an amino acid with the opposite charge is introduced into the human sequence or (B) one or several codons for a charged amino acid which are found in the factor VIII cDNA of a hemophilic patient are replaced with a codon for an amino acid of the opposite charge. COPYRIGHT: (C)2004,JPO&NCIPI