PRODUCTION METHOD OF CLAVULANIC ACID

PROBLEM TO BE SOLVED: To provide a new clavulanic acid intermediate by an enzyme reaction and a reaction process in its conversion to clavulanic acid. SOLUTION: An enzyme having amidinohydrolase activity is obtained by centrifugation and ultrasonication of Streptomyces clavuligerus ATCC27064 mycelia...

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Hauptverfasser:	BALDWIN JACK EDWARD, NICHOLSON NEVILLE HUBERT, SCHOFIELD CHRISTOPHER, EDWARDS JEFFREY, BAGGALEY KEITH HOWARD, ELSON STEPHEN WILLIAM, EARL ALISON JANE, HOLMS WILLIAM HENRY, MOUSDALE DAVID MICHAEL
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a new clavulanic acid intermediate by an enzyme reaction and a reaction process in its conversion to clavulanic acid. SOLUTION: An enzyme having amidinohydrolase activity is obtained by centrifugation and ultrasonication of Streptomyces clavuligerus ATCC27064 mycelia usable for a reaction in the conversion process from the intermediate to the clavulanic acid and subsequently by separation of them through ion exchange chromatography. COPYRIGHT: (C)2004,JPO