THIENYL-, FURYL-, PYRROLYL-, AND BIPHENYL-SULFONAMIDE AND THEIR DERIVATIVE REGULATING ACTIVITY OF ENDOTHELIN
PROBLEM TO BE SOLVED: To provide a compound having ability for regulating biological activity of one or more endothelin isopeptides. SOLUTION: The compounds which adjust or change the activity of peptides of an endothelin family comprise thienyl-, furyl-, and pyrrolyl-sulfonamides. A method for prev...
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| creator | CASTILLO ROSARIO S CHAN MING FAI KOGAN TIMOTHY BALAJI VITUKUDI N YALAMOORI VENKATACHALAPATHI RAJU BORE G VERNER ERIK JOEL WU CHENGDE KOIS ADAM |
| description | PROBLEM TO BE SOLVED: To provide a compound having ability for regulating biological activity of one or more endothelin isopeptides. SOLUTION: The compounds which adjust or change the activity of peptides of an endothelin family comprise thienyl-, furyl-, and pyrrolyl-sulfonamides. A method for preventing the endothelin peptide from combining with an endthelin receptor comprises contacting the receptor with the sulfonamide, especially, N-(isoxazolyl)thienylsulfonamide, N-(isoxazolyl)furylsulfonamide, and N-(isoxazolyl)pyrrolylsulfonamide. A method for treating diseases mediated by the endothelin comprises administering an effective amount of one or more kinds of the sulfonamides or their prodrugs which inhibit or enhance the endothelin activity. COPYRIGHT: (C)2004,JPO |
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SOLUTION: The compounds which adjust or change the activity of peptides of an endothelin family comprise thienyl-, furyl-, and pyrrolyl-sulfonamides. A method for preventing the endothelin peptide from combining with an endthelin receptor comprises contacting the receptor with the sulfonamide, especially, N-(isoxazolyl)thienylsulfonamide, N-(isoxazolyl)furylsulfonamide, and N-(isoxazolyl)pyrrolylsulfonamide. A method for treating diseases mediated by the endothelin comprises administering an effective amount of one or more kinds of the sulfonamides or their prodrugs which inhibit or enhance the endothelin activity. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | THIENYL-, FURYL-, PYRROLYL-, AND BIPHENYL-SULFONAMIDE AND THEIR DERIVATIVE REGULATING ACTIVITY OF ENDOTHELIN |
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