METHOD FOR PRODUCING 4-TRIFLUOROMETHYLNICOTINIC ACID OR ITS SALT

METHOD FOR PRODUCING 4-TRIFLUOROMETHYLNICOTINIC ACID OR ITS SALT

PROBLEM TO BE SOLVED: To provide a method for producing 4-trifluoromethylnicotinic acid while suppressing the lowering of yield caused by the by-production of 6-trifluoromethylnicotinic acid. SOLUTION: 1,3-Dimethyl-2-imidazolidinone is used as a solvent for the condensation reaction in the productio...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: YOSHIZAWA HIROSHI, HATTORI MASASHI, MIYAJI MIKIO, SAWAKI MASAHIKO, NAGASE TETSUYA, MURAKAMI KATSUMI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method for producing 4-trifluoromethylnicotinic acid while suppressing the lowering of yield caused by the by-production of 6-trifluoromethylnicotinic acid. SOLUTION: 1,3-Dimethyl-2-imidazolidinone is used as a solvent for the condensation reaction in the production of the compound of formula (IV) or its salt by the condensation reaction of the compound of formula (I) with a compound of formula (II-I): (R1O)2CHCH2-CO2R or formula (II-2): R1O-CH=CH-CO2R, cyclizing the produced compound of formula (III) or its salt and hydrolyzing the product. COPYRIGHT: (C)2004,JPO