PREPARATION OF VASCULAR ENDOTHELIAL CELL GROWTH FACTOR

PROBLEM TO BE SOLVED: To provide a method for production of wound treating agents having a mitogenicity to vascular endothelial cells accordingly useful for promotion of vascularization (vasculogenesis) and production of endodermis of intravascular surface, and to provide a method for production of...

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Hauptverfasser:	MITCHELL RICHARD L, TISCHER EDMUND G, ABRAHAM JUDITH A, FIDDES JOHN C
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for production of wound treating agents having a mitogenicity to vascular endothelial cells accordingly useful for promotion of vascularization (vasculogenesis) and production of endodermis of intravascular surface, and to provide a method for production of the vascular endothelial cell growth factor by a recombinant DNA technology. SOLUTION: The method which produces an isolated DNA encoding the vascular endothelial cell growth factor of a mammal and the vascuar endothelial cell growth factor, comprises (a) a step culturing cells transformed by an expressing vector containing a DNA sequence encoding the amino acid sequence of a polypeptide chain of the vascular endothelial cell in a condition in which the polypeptide is expressed, (b) a step collecting the expressed polypeptide and (c) a step forming a disulfide link on the polypeptide chain. COPYRIGHT: (C)2004,JPO