INTERMEDIATE FOR PRODUCING (+)-CALANOLIDE A, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING (+)- CALANOLIDE A USING THE SAME

INTERMEDIATE FOR PRODUCING (+)-CALANOLIDE A, METHOD FOR PRODUCING THE SAME, AND METHOD FOR PRODUCING (+)- CALANOLIDE A USING THE SAME

PROBLEM TO BE SOLVED: To provide intermediates for producing (+)-calanolide A, to provide method(s) for producing the intermediate(s), and to provide a method for producing the (+)-calanolide A using the intermediates. SOLUTION: First, (±)-chromanone (II) is subjected to optical resolution using an...

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Bibliographische Detailangaben
Hauptverfasser: TERAJIMA ATSURO, KOYAKUMARU KENICHI
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
SEPARATION
TRANSPORTING
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide intermediates for producing (+)-calanolide A, to provide method(s) for producing the intermediate(s), and to provide a method for producing the (+)-calanolide A using the intermediates. SOLUTION: First, (±)-chromanone (II) is subjected to optical resolution using an optically active amine to obtain (+)-chromanone (I), which is then reacted with 3-methyl-2-butenal to obtain (+)-12-oxocalanolide A (III), which is then reduced to obtain the objective (+)-calanolide A (IV). COPYRIGHT: (C)2004,JPO