NUCLEIC ACID MOLECULE, POLYPEPTIDE AND USE THEREFOR INCLUDING DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE

PROBLEM TO BE SOLVED: To provide a method for the screening, diagnosis and prognosis of Alzheimer's disease of mammals, the identification of mammals having high risk of the disease and the monitoring of the effectiveness of a treatment applied to a mammal of Alzheimer's disease. SOLUTION:...

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Hauptverfasser:	WILLIAMS STEPHEN A, PAREKH RAJESH BHIKHU, TOWNSEND ROBERT REID, STIGER THOMAS R, ROHLFF CHRISTIAN, SNYDER PETER JEFFREY, DURHAM L KATHRYN, KIMMEL LIDA H, WHITE W FROST, POTTER DAVID M, FRIEDMAN DAVID L, HERATH HERATH MUDIYANSELAGE A C, SUNDERLAND P TREY, SILBER B MICHAEL, SOARES HOLLY DARIA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for the screening, diagnosis and prognosis of Alzheimer's disease of mammals, the identification of mammals having high risk of the disease and the monitoring of the effectiveness of a treatment applied to a mammal of Alzheimer's disease. SOLUTION: The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's disease-associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's disease-associated protein isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same. COPYRIGHT: (C)2004,JPO