BRANCHED AMINO ACID-DEPENDENT AMINOTRANSFERASE INHIBITOR AND ITS USE ON NEURODEGENERATIVE DISEASE

PROBLEM TO BE SOLVED: To provide a branched amino acid-dependent aminotransferase inhibitor. SOLUTION: This compound represented by formula äfor example, methyl [2-(2, 6-dichloro-phenylamino)-4-oxo-4H-thiazol-5-ylidene]-acetate}. The compound is useful for a method for treating or preventing cerebra...

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Hauptverfasser:	WUSTROW DAVID JUERGEN, HAYS SHERYL JEANNE, HU LAIN-YEN, LEI HUANGSHU, SCHOLTEN JEFFREY DAVID
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a branched amino acid-dependent aminotransferase inhibitor. SOLUTION: This compound represented by formula äfor example, methyl [2-(2, 6-dichloro-phenylamino)-4-oxo-4H-thiazol-5-ylidene]-acetate}. The compound is useful for a method for treating or preventing cerebral apoplexy, ischemia, CNS trauma, hypoglycemia, and neuronal deficiency, a method for treating a neurodegenerative disease (for example, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's chorea, Parkinson's disease, and Down's syndrome), a method for treating or preventing disadvantageous effects caused by the excessive stimulation of excitatory amino acids, a method for treating anxiety, mental diseases, convulsion, aminoglycoside antibiotic-induced hypacusis, migrainechronic ache, neuropathic ache, Parkinson's disease, diabetic retinopathy, glaucoma, CMV retinopathy, incontinence, opioid-resistant or withdrawal symptoms, and a method for improving recognition. COPYRIGHT: (C)2003,JPO