METHOD FOR IDENTIFYING METALLOENZYME INHIBITOR

PROBLEM TO BE SOLVED: To provide a method for identifying a metalloenzyme inhibitor including a matrix metalloproteinase (MMP) inhibitor which is a competitive, noncompetitive or uncompetitive inhibitor. SOLUTION: This method for identifying the metalloenzyme inhibitor includes processes (a) to (f)...

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Bibliographische Detailangaben
Hauptverfasser:	HUPE DONALD JOHN, DYER RICHARD DENNIS, JOHNSON ADAM RICHARD
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PHYSICS PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for identifying a metalloenzyme inhibitor including a matrix metalloproteinase (MMP) inhibitor which is a competitive, noncompetitive or uncompetitive inhibitor. SOLUTION: This method for identifying the metalloenzyme inhibitor includes processes (a) to (f) as follows: (a) a process for forming a first control mixture; (b) a process for forming a second control mixture; (c) a process for forming a first compound mixture; (d) a process for forming a second compound mixture; (e) a process for determining inhibition of the matalloenzyme in the process (c) by comparing activity of the metalloenzyme in the process (c) with control activity of the metalloenzyme in the process (a); (f) a process for determining inhibition of the matalloenzyme in the process (d) by comparing activity of the metalloenzyme in the process (d) with control activity of the metalloenzyme in the process (b); and (g) a process for comparing the inhibition determined in the process (e) with the inhibition determined in the process (f).