COMPLEX OF PROTEIN AND PHOSPHATIDYLETHANOLAMINE

PROBLEM TO BE SOLVED: To show a substance X forming a complex with Apg8FG, explain the structure of formed Apg8FG-X, show the action of protein such as the Apg8FG and its derivative, the Apg8FG-X, to a phospholipid forming a membrane, and provide a method for producing and utilizing a new phospholip...

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Hauptverfasser:	KIRIEKI TAKAYOSHI, TAKAO TOSHIFUMI, NODA KENJI, OSUMI YOSHINORI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To show a substance X forming a complex with Apg8FG, explain the structure of formed Apg8FG-X, show the action of protein such as the Apg8FG and its derivative, the Apg8FG-X, to a phospholipid forming a membrane, and provide a method for producing and utilizing a new phospholipid- protein binder formed by a covalent bond of the protein and the phospholipid. SOLUTION: In this reversible method for producing the phospholipid-protein complex formed by the covalent bond of the phospholipid and the protein by an amide bond, the phospholipid is phosphatidylethanolamine, the protein is Apg8 with the C-terminal of glycine or its derivative, and an amino group of the phospholipid and a carboxyl group of the C-terminal of the protein make the amide bond into the phospholipid-protein complex. And it is used for an autophagy modifier for the cell composed of the phospholipid-protein binder, that is to say an autophagy modifier for the cure, prevention, or treatment of cancer or Alzheimer disease.