DRUG DISCHARGING PUMP INHIBITOR

PROBLEM TO BE SOLVED: To obtain a medicine for prophylaxis and/or therapy of microbisms having removal actions on tolerance from a microoganism acquiring drug tolerance. SOLUTION: This medicine for prophylaxis and/or therapy of the microbisms comprises a compound represented by formula (I) [R and R denote each hydrogen atom, a halogen atom, carboxy group, or the like; J denotes a five- or a six-membered aromatic heterocyclic ring; W denotes CH=CH, CH≡CH, CH2 CH2 , or the like; A denotes phenylene group, pyridinediyl group, furandiyl group, or the like; G denotes oxygen atom, carbonyl group, ethynyl group, or the like; (p) denotes an integer of 0-3; G denotes phenylene group, furandiyl group, tetrahydrofurandiyl group, or the like; G denotes CH2 or a single bond; (m) and (n) denote each an integer of 0 or 1: and Q denotes an acidic group] as an active ingredient and used for combined use with one or more kinds of antimicrobial agents.