SINGLE-CHAIN INSULIN ANALOGUE FOR TREATING DIABETES AND VECTOR INCLUDING GENE ENCODING THE SAME

PROBLEM TO BE SOLVED: To provide a method for introducing, into at least one mammalian tissue in its host, at least one single-chain insulin analogue(SIA) protein to be used for treating diabetes of a mammal or a gene encoding the SIA, and to provide a recombinant vector including the SIA or the gen...

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Bibliographische Detailangaben
Hauptverfasser:	YOON JI-WON, KIM KYUNG-SUP, LEE HYUN CHUL, KIM SU-JIN, SHIN HANGOL
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To provide a method for introducing, into at least one mammalian tissue in its host, at least one single-chain insulin analogue(SIA) protein to be used for treating diabetes of a mammal or a gene encoding the SIA, and to provide a recombinant vector including the SIA or the gene encoding the SIA. SOLUTION: A method for treating diabetes, more specifically autoimmune I-type diabetes and insulin-deficient II-type diabetes, comprises expressing an SIA in hepatocyte under the control of a hepatocyte-specific glucose regulatory promoter and, if necessary, an SV40 enhancer.