DECARBAMILASE COMPLEX
PROBLEM TO BE SOLVED: To provide a 3D-structural coordinates by obtaining a monocrystal of a complex of decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, followed by crystal structure analysis with X-ray, and to provide an excellent decarbamilase isomer which...
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creator | NANBA HIRONORI NAKAI TAKANAO MORIKAWA SOICHI |
description | PROBLEM TO BE SOLVED: To provide a 3D-structural coordinates by obtaining a monocrystal of a complex of decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, followed by crystal structure analysis with X-ray, and to provide an excellent decarbamilase isomer which is more advantageous for industrial purpose than the natural decarbamilase by designing a molecule with aims of improving the reactivity against a D-N-carbamoyl-α-amino acid, which is a substrate, optimizing the reactive pH, modifying substrate specificity and others by using the 3D-structural coordinates. SOLUTION: The steric structure of the complex of the decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, determined by crystal structure analysis with X-ray. The molecular design technique using the steric structure. A method for obtaining a decarbamilase isomer using the technique. Further, a decarbamilase isomer obtained by the technique. |
format | Patent |
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SOLUTION: The steric structure of the complex of the decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, determined by crystal structure analysis with X-ray. The molecular design technique using the steric structure. A method for obtaining a decarbamilase isomer using the technique. Further, a decarbamilase isomer obtained by the technique.</description><edition>7</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2002</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021022&DB=EPODOC&CC=JP&NR=2002306178A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20021022&DB=EPODOC&CC=JP&NR=2002306178A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NANBA HIRONORI</creatorcontrib><creatorcontrib>NAKAI TAKANAO</creatorcontrib><creatorcontrib>MORIKAWA SOICHI</creatorcontrib><title>DECARBAMILASE COMPLEX</title><description>PROBLEM TO BE SOLVED: To provide a 3D-structural coordinates by obtaining a monocrystal of a complex of decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, followed by crystal structure analysis with X-ray, and to provide an excellent decarbamilase isomer which is more advantageous for industrial purpose than the natural decarbamilase by designing a molecule with aims of improving the reactivity against a D-N-carbamoyl-α-amino acid, which is a substrate, optimizing the reactive pH, modifying substrate specificity and others by using the 3D-structural coordinates. SOLUTION: The steric structure of the complex of the decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, determined by crystal structure analysis with X-ray. The molecular design technique using the steric structure. A method for obtaining a decarbamilase isomer using the technique. Further, a decarbamilase isomer obtained by the technique.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2002</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB1cXV2DHJy9PX0cQx2VXD29w3wcY3gYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBgZGxgZmhuYWjsZEKQIAzPAfPw</recordid><startdate>20021022</startdate><enddate>20021022</enddate><creator>NANBA HIRONORI</creator><creator>NAKAI TAKANAO</creator><creator>MORIKAWA SOICHI</creator><scope>EVB</scope></search><sort><creationdate>20021022</creationdate><title>DECARBAMILASE COMPLEX</title><author>NANBA HIRONORI ; NAKAI TAKANAO ; MORIKAWA SOICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2002306178A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2002</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>NANBA HIRONORI</creatorcontrib><creatorcontrib>NAKAI TAKANAO</creatorcontrib><creatorcontrib>MORIKAWA SOICHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NANBA HIRONORI</au><au>NAKAI TAKANAO</au><au>MORIKAWA SOICHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DECARBAMILASE COMPLEX</title><date>2002-10-22</date><risdate>2002</risdate><abstract>PROBLEM TO BE SOLVED: To provide a 3D-structural coordinates by obtaining a monocrystal of a complex of decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, followed by crystal structure analysis with X-ray, and to provide an excellent decarbamilase isomer which is more advantageous for industrial purpose than the natural decarbamilase by designing a molecule with aims of improving the reactivity against a D-N-carbamoyl-α-amino acid, which is a substrate, optimizing the reactive pH, modifying substrate specificity and others by using the 3D-structural coordinates. SOLUTION: The steric structure of the complex of the decarbamilase and a D-N-carbamoyl-α-amino acid, which is a substrate of the decarbamilase, determined by crystal structure analysis with X-ray. The molecular design technique using the steric structure. A method for obtaining a decarbamilase isomer using the technique. Further, a decarbamilase isomer obtained by the technique.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
title | DECARBAMILASE COMPLEX |
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