METHOD FOR PRODUCING ESTRA-4,6-DIENE-3,17-DIONE

METHOD FOR PRODUCING ESTRA-4,6-DIENE-3,17-DIONE

PROBLEM TO BE SOLVED: To provide a simple method for producing estra-4,6-diene-3,17-dione useful as an intermediate for producing medicines and the like from a 3- substituted oxyestra-3,5-dien-17-one. SOLUTION: This target compound, estra-4,6-diene-3,17-dione represented by formula (2) is produced b...

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Bibliographische Detailangaben
Hauptverfasser: YAMAGAMI RYUTARO, TERADA TADASHI, YANO SHINGO, ASAO TETSUJI, SATO TSUTOMU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Zusammenfassung:PROBLEM TO BE SOLVED: To provide a simple method for producing estra-4,6-diene-3,17-dione useful as an intermediate for producing medicines and the like from a 3- substituted oxyestra-3,5-dien-17-one. SOLUTION: This target compound, estra-4,6-diene-3,17-dione represented by formula (2) is produced by reacting the 3-substituted oxyestra-3,5-dien-17-one represented by formula (1) with a halogenating agent such as N- bromosuccinimide and then reacting the reaction product with an alkali metal carbonate such as lithium carbonate.