METHOD OF PRODUCTION FOR CLEATINE CONTAINING SOLID ADMINISTRATION AND ADMINISTRATION OBTAINED BY THE SAME
PROBLEM TO BE SOLVED: To produce a novel creatine containing solid administration by a melt calendering. SOLUTION: This creatine-containing solid administration form is produced by (a) preparing a mixture containing at least one of high-molecular weight binders having thermoplastic physiologically p...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To produce a novel creatine containing solid administration by a melt calendering. SOLUTION: This creatine-containing solid administration form is produced by (a) preparing a mixture containing at least one of high-molecular weight binders having thermoplastic physiologically permissible water-solubility or water-swelling property, creatine and water of 1-20 mol based on 1 mol of creatine, (b) plasticizing this mixture at the softening point of the high-molecular weight binders or over this softening point and (c) molding the plasticized mixture to the administration form and cooling. |
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