5'-MODIFIED OLIGONUCLEOTIDE

5'-MODIFIED OLIGONUCLEOTIDE

PROBLEM TO BE SOLVED: To obtain a new modified phoshorous acid intermediate used for various types of method for synthesizing an oligonucleotide and having an activable group convertible into a free aldehyde group or sulfhydryl group when the intermediate is once added to the 5'-terminal of the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CONRAD MICHAEL J, JONES DAVID S, HACHMANN JOHN P, COUTTS STEPHEN, LIVINGSTON DOUGLAS A
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To obtain a new modified phoshorous acid intermediate used for various types of method for synthesizing an oligonucleotide and having an activable group convertible into a free aldehyde group or sulfhydryl group when the intermediate is once added to the 5'-terminal of the oligonucleotide. SOLUTION: This compound is represented by the general formula 1 (X2 is RO or the like, X1 is NR1R2 or the like; R1 and R2 are each a 1-2C alkyl group or the like or, together with N, may assume a ring type structure; G is a 2-20C hydrocarbylene group; and Z is a hydroxy-protected vicinal diol group bound to G with one of vicinal diol group carbon atoms).