MACROLIDE-BASED COMPOUND
PROBLEM TO BE SOLVED: To obtain a new compound having antimicrobial action not only on erythromycin-sensitive microorganism, but also on erythromycin-resistant microorganism such as streptococcus by introducing a substituted oxime group into a position adjacent to ester-carbonyl group. SOLUTION: Thi...
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| creator | ASAGA TOSHIBUMI TANIGAWA TETSUYA KASHIMURA MASATO SUGIMOTO TOMOHIRO MANNAKA AKIRA |
| description | PROBLEM TO BE SOLVED: To obtain a new compound having antimicrobial action not only on erythromycin-sensitive microorganism, but also on erythromycin-resistant microorganism such as streptococcus by introducing a substituted oxime group into a position adjacent to ester-carbonyl group. SOLUTION: This compound is represented by formula I R1 is H, a 1-3C alkyl or the like; R2 is a 2-8C alkyl containing O or the like, H or the like, R3 is pyridyl, thiazolyl or the like; X is a group of formula II or III [R4 is H or methyl; R5 is a (substituted) benzenesulfonyl or the like; R6 and R7 are each H or methyl] or the like, e.g. 11-[2-[N-methyl-N-(3-pyridylmethyl) amino]ethyl]amino-11-eoxy-3-0-[2-pyridyl)-2-hydroxyimino]acetyl-5-0- desosaminyl-6-0-methylerythronolide A 11,12-cyclic carbamate. The compound of formula I is produced by method, etc., reacting a compound of formula V derived from a compound of formula IV with nitrous acid (salt). |
| format | Patent |
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SOLUTION: This compound is represented by formula I R1 is H, a 1-3C alkyl or the like; R2 is a 2-8C alkyl containing O or the like, H or the like, R3 is pyridyl, thiazolyl or the like; X is a group of formula II or III [R4 is H or methyl; R5 is a (substituted) benzenesulfonyl or the like; R6 and R7 are each H or methyl] or the like, e.g. 11-[2-[N-methyl-N-(3-pyridylmethyl) amino]ethyl]amino-11-eoxy-3-0-[2-pyridyl)-2-hydroxyimino]acetyl-5-0- desosaminyl-6-0-methylerythronolide A 11,12-cyclic carbamate. The compound of formula I is produced by method, etc., reacting a compound of formula V derived from a compound of formula IV with nitrous acid (salt).</description><edition>7</edition><language>eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>2001</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010321&DB=EPODOC&CC=JP&NR=2001072699A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20010321&DB=EPODOC&CC=JP&NR=2001072699A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ASAGA TOSHIBUMI</creatorcontrib><creatorcontrib>TANIGAWA TETSUYA</creatorcontrib><creatorcontrib>KASHIMURA MASATO</creatorcontrib><creatorcontrib>SUGIMOTO TOMOHIRO</creatorcontrib><creatorcontrib>MANNAKA AKIRA</creatorcontrib><title>MACROLIDE-BASED COMPOUND</title><description>PROBLEM TO BE SOLVED: To obtain a new compound having antimicrobial action not only on erythromycin-sensitive microorganism, but also on erythromycin-resistant microorganism such as streptococcus by introducing a substituted oxime group into a position adjacent to ester-carbonyl group. SOLUTION: This compound is represented by formula I R1 is H, a 1-3C alkyl or the like; R2 is a 2-8C alkyl containing O or the like, H or the like, R3 is pyridyl, thiazolyl or the like; X is a group of formula II or III [R4 is H or methyl; R5 is a (substituted) benzenesulfonyl or the like; R6 and R7 are each H or methyl] or the like, e.g. 11-[2-[N-methyl-N-(3-pyridylmethyl) amino]ethyl]amino-11-eoxy-3-0-[2-pyridyl)-2-hydroxyimino]acetyl-5-0- desosaminyl-6-0-methylerythronolide A 11,12-cyclic carbamate. The compound of formula I is produced by method, etc., reacting a compound of formula V derived from a compound of formula IV with nitrous acid (salt).</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJDwdXQO8vfxdHHVdXIMdnVRcPb3DfAP9XPhYWBNS8wpTuWF0twMSm6uIc4euqkF-fGpxQWJyal5qSXxXgFGBgaGBuZGZpaWjsZEKQIAKtcgHA</recordid><startdate>20010321</startdate><enddate>20010321</enddate><creator>ASAGA TOSHIBUMI</creator><creator>TANIGAWA TETSUYA</creator><creator>KASHIMURA MASATO</creator><creator>SUGIMOTO TOMOHIRO</creator><creator>MANNAKA AKIRA</creator><scope>EVB</scope></search><sort><creationdate>20010321</creationdate><title>MACROLIDE-BASED COMPOUND</title><author>ASAGA TOSHIBUMI ; TANIGAWA TETSUYA ; KASHIMURA MASATO ; SUGIMOTO TOMOHIRO ; MANNAKA AKIRA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2001072699A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2001</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>ASAGA TOSHIBUMI</creatorcontrib><creatorcontrib>TANIGAWA TETSUYA</creatorcontrib><creatorcontrib>KASHIMURA MASATO</creatorcontrib><creatorcontrib>SUGIMOTO TOMOHIRO</creatorcontrib><creatorcontrib>MANNAKA AKIRA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ASAGA TOSHIBUMI</au><au>TANIGAWA TETSUYA</au><au>KASHIMURA MASATO</au><au>SUGIMOTO TOMOHIRO</au><au>MANNAKA AKIRA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MACROLIDE-BASED COMPOUND</title><date>2001-03-21</date><risdate>2001</risdate><abstract>PROBLEM TO BE SOLVED: To obtain a new compound having antimicrobial action not only on erythromycin-sensitive microorganism, but also on erythromycin-resistant microorganism such as streptococcus by introducing a substituted oxime group into a position adjacent to ester-carbonyl group. SOLUTION: This compound is represented by formula I R1 is H, a 1-3C alkyl or the like; R2 is a 2-8C alkyl containing O or the like, H or the like, R3 is pyridyl, thiazolyl or the like; X is a group of formula II or III [R4 is H or methyl; R5 is a (substituted) benzenesulfonyl or the like; R6 and R7 are each H or methyl] or the like, e.g. 11-[2-[N-methyl-N-(3-pyridylmethyl) amino]ethyl]amino-11-eoxy-3-0-[2-pyridyl)-2-hydroxyimino]acetyl-5-0- desosaminyl-6-0-methylerythronolide A 11,12-cyclic carbamate. The compound of formula I is produced by method, etc., reacting a compound of formula V derived from a compound of formula IV with nitrous acid (salt).</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | MACROLIDE-BASED COMPOUND |
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