EXPRESSION REGULATORY SEQUENCE OF GENE

PROBLEM TO BE SOLVED: To obtain a polynucleotide capable of specifying an expression promoter and an expression inhibitor of nerve cell apoptosis inhibitory protein(NAIP) and diagnosing apoptotic diseases by making the polynucleotide have a specific base sequence. SOLUTION: This polynucleotide compr...

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Hauptverfasser:	IKEDA SHIGEMORI, JO AKIRA
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain a polynucleotide capable of specifying an expression promoter and an expression inhibitor of nerve cell apoptosis inhibitory protein(NAIP) and diagnosing apoptotic diseases by making the polynucleotide have a specific base sequence. SOLUTION: This polynucleotide comprises a base sequence of 765 base to 416 base of the formula or its partial sequence and promotes gene expression. A polynucleotide comprising a base sequence of 482 base to 416 base of the formula and functioning as a gene promoter, a polynucleotide comprising a base sequence of 646 base to 531 base of the formula and functioning as a gene enhancer and a polynucleotide comprising a base sequence of 421 base to 202 base of the formula and functioning as a gene silencer are prepared. A candidate substance is added to a culture medium of a cell transfected with a recombinant vector having a reporter gene connected to the polynucleotide. The expression promoter of NAIP is preferably specified by using the expression amount of a reporter gene as an index.