METHOD AND MEDICINAL AGENT FOR INHIBITING REPLICATION OF VIRUS
PROBLEM TO BE SOLVED: To obtain a new enzymic RNA molecule having an activity for specifically cleaving a specific base sequence of a hepatitis C virus or the like or a genomic RNA or an mRNA or an hnRNA encoded by the virus and useful as an inhibitor of replication, infection and genetic expression...
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| creator | MACEJAK DENNIS G DRAPER KENNETH G MAMONE J ANTHONY DUDYCZ LECH W HOLECEK JAMES J MCSWIGGEN JAMES A |
| description | PROBLEM TO BE SOLVED: To obtain a new enzymic RNA molecule having an activity for specifically cleaving a specific base sequence of a hepatitis C virus or the like or a genomic RNA or an mRNA or an hnRNA encoded by the virus and useful as an inhibitor of replication, infection and genetic expression of a virus. SOLUTION: This new enzymic RNA molecule has an activity for specifically cleaving a base sequence such as formulae I to III of a hepatitis C virus or a genomic RNA or an mRNA or an hnRNA encoded with the virus and is useful as an inhibitor, etc., of replication, infection and genetic expression of a virus for treatment of viral infection with picornavirus, HIV-1, HIV-2, HBV, papillomavirus, EBV, HTLV-I, HCV, CMV or influenza virus. The enzymic RNA molecule is obtained by selecting a sequence formed of a motif of a hammerhead having a specific substrate binding site complementary to a target viral gene RNA region. |
| format | Patent |
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SOLUTION: This new enzymic RNA molecule has an activity for specifically cleaving a base sequence such as formulae I to III of a hepatitis C virus or a genomic RNA or an mRNA or an hnRNA encoded with the virus and is useful as an inhibitor, etc., of replication, infection and genetic expression of a virus for treatment of viral infection with picornavirus, HIV-1, HIV-2, HBV, papillomavirus, EBV, HTLV-I, HCV, CMV or influenza virus. 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SOLUTION: This new enzymic RNA molecule has an activity for specifically cleaving a base sequence such as formulae I to III of a hepatitis C virus or a genomic RNA or an mRNA or an hnRNA encoded with the virus and is useful as an inhibitor, etc., of replication, infection and genetic expression of a virus for treatment of viral infection with picornavirus, HIV-1, HIV-2, HBV, papillomavirus, EBV, HTLV-I, HCV, CMV or influenza virus. 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SOLUTION: This new enzymic RNA molecule has an activity for specifically cleaving a base sequence such as formulae I to III of a hepatitis C virus or a genomic RNA or an mRNA or an hnRNA encoded with the virus and is useful as an inhibitor, etc., of replication, infection and genetic expression of a virus for treatment of viral infection with picornavirus, HIV-1, HIV-2, HBV, papillomavirus, EBV, HTLV-I, HCV, CMV or influenza virus. The enzymic RNA molecule is obtained by selecting a sequence formed of a motif of a hammerhead having a specific substrate binding site complementary to a target viral gene RNA region.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TESTING VINEGAR WINE |
| title | METHOD AND MEDICINAL AGENT FOR INHIBITING REPLICATION OF VIRUS |
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