PRODUCTION OF 2-ISOXAZOLINE COMPOUND HAVING UNSATURATED GROUP AT 3-POSITION
PROBLEM TO BE SOLVED: To easily obtain, using easily available raw materials, the subject compound having no substitutents at the 4- and 5-positions of the isoxazoline and having an unsaturated group at the 3-position thereof, by reacting a specified compound with an unsaturated Grignard reagent. SO...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To easily obtain, using easily available raw materials, the subject compound having no substitutents at the 4- and 5-positions of the isoxazoline and having an unsaturated group at the 3-position thereof, by reacting a specified compound with an unsaturated Grignard reagent. SOLUTION: This compound of formula II is obtained by reacting (A) a 3-sulfonyl-2-isoxazoline of formula I [R is a 1-6C alkyl or a (substituted) aryl] with (B) an unsaturated Grignard reagent of the formula R1MgX (R1 is a 2-6C alkenyl or a 2-6C alkynyl; X is a halogen) in (C) a solvent at room temperature or, as necessary, by heating to the boiling point of the solvent. The component A can be produced by the process described in the Japanese Patent Application No.11-105606. As a component C, an ether such as diethyl ether or tetrahydrofuran, and/or an aromatic hydrocarbon such as benzene, toluene or xylene, is used. |
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