PROPHYLACTIC OR THERAPEUTIC AGENT FOR ONSET OF ARTERIOSCLEROTIC DISEASE CONTAINING ORGANOGERMANIUM COMPOUND AS ACTIVE INGREDIENT

PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for arteriosclerotic diseases in which MCP-1 participates. SOLUTION: An organogermanium compound represented by the formula [(O1/2)3Ge-A-CO2H]n (n is >=1; A is a lower alkyl group) remarkably suppresses MCP-1 receptor antagonism,...

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Hauptverfasser:	SHIMOKAWA HIROAKI, ISHIWATARI YOSHIRO, HASHIMOTO HIROYUKI, YOKOCHI SHOJI
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	SHIMOKAWA HIROAKI ISHIWATARI YOSHIRO HASHIMOTO HIROYUKI YOKOCHI SHOJI
description	PROBLEM TO BE SOLVED: To obtain a prophylactic or therapeutic agent for arteriosclerotic diseases in which MCP-1 participates. SOLUTION: An organogermanium compound represented by the formula [(O1/2)3Ge-A-CO2H]n (n is >=1; A is a lower alkyl group) remarkably suppresses MCP-1 receptor antagonism, e.g. chemotaxis such as monocyte which is brought about by MCP-1. The compound becomes a prophylactic or therapeutic agent which is effective to arteriosclerotic diseases in which MCP-1 participates.
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subjects	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	PROPHYLACTIC OR THERAPEUTIC AGENT FOR ONSET OF ARTERIOSCLEROTIC DISEASE CONTAINING ORGANOGERMANIUM COMPOUND AS ACTIVE INGREDIENT
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