ANTIBODY AGAINST CARBOXYMETHYLATED PROTEIN

PROBLEM TO BE SOLVED: To obtain an antibody which reacts with an amino acid having a carboxymethylated amino group on a side chain and existing in a protein or the like, does not react with an amino acid having a carboxyethylated amino group on a side chain, and is useful for detecting diabetic comp...

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Bibliographische Detailangaben
Hauptverfasser:	NAGAI TATSUJI, HORIUCHI MASAKIMI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain an antibody which reacts with an amino acid having a carboxymethylated amino group on a side chain and existing in a protein or the like, does not react with an amino acid having a carboxyethylated amino group on a side chain, and is useful for detecting diabetic complications or the like. SOLUTION: This antibody reacts with an amino acid which exists in a protein or a peptide and whose amino acid on a side chain is carboxymethylated, such as -carboxymethyllysine, but does not react with an amino acid whose amino acid on a side chain is carboxyethylated. The antibody is preferably a polyclonal antibody or a monoclonal antibody, and is preferably produced using a hybridoma deposited as FERM P-17153. A method for detecting a diabetic complication comprises reacting the antibody with a protein or peptide which partially contains an amino acid whose amino acid on a side chain is carboxymethylated. A method for producing a protein or peptide comprises collecting the protein or peptide from the obtained reaction products.