ANTITUMOR SUBSTANCE BE-54017, AND ITS PRODUCTION

PROBLEM TO BE SOLVED: To obtain he subject novel compound, showing an antitumor function by suppressing growth of tumor cells. SOLUTION: This compound is shown by the formula, which belongs to Streptomyces. It is obtained by culturing a microorganism capable of producing the compound shown by the fo...

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Hauptverfasser:	HIRAYAMA MIOKO, NAKAJIMA SHIGERU, SUDA HIROYUKI, NAKASE KAZUHO, OJIRI KATSUHISA, KONDO HISAO
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain he subject novel compound, showing an antitumor function by suppressing growth of tumor cells. SOLUTION: This compound is shown by the formula, which belongs to Streptomyces. It is obtained by culturing a microorganism capable of producing the compound shown by the formula, e.g. Streptomyces sp. A54017, FERM P-16952 or its variant preferably at 14 to 34 deg.C and pH 4 to 8 for 24 to 168 hours, and recovering the compound from the culture system by an adequate separation method, e.g. solvent extraction and ion-exchanging with a resin. When this compound is used as an antitumor agent, it is preferably administered at 10 to 50 mg/day for an adult for oral administration, and 10 to 100 mg/day for parenteral ad ministration, preferably intravenous injection.