MCP-1 RECEPTOR ANTAGONIST CONTAINING ORGANIC GERMANIUM COMPOUND AND PREVENTIVE OR TREATING AGENT FOR ONSET OF INFLAMMATORY DISEASE OR ORGANOPATHY RELATING TO MCP-1
PROBLEM TO BE SOLVED: To obtain an MCP-1 receptor antagonist useful for inflammatory disease or organopathy relating to MCP-1 by including an organic germanium compound as an active component. SOLUTION: This MCP-1 receptor antagonist contains an organic germanium compound of formula: [(O1/2)3Ge-A-CO...
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Zusammenfassung: | PROBLEM TO BE SOLVED: To obtain an MCP-1 receptor antagonist useful for inflammatory disease or organopathy relating to MCP-1 by including an organic germanium compound as an active component. SOLUTION: This MCP-1 receptor antagonist contains an organic germanium compound of formula: [(O1/2)3Ge-A-CO2H]n (n)>=1; A is a lower alkyl}, preferably 3-oxygelmyl propionic acid 8-membered structural material of the formula R is -CH2CH2COOH, (m) is weight-average molecular weight of 137±84 reduced from weight-average molecular weight of propagermanium propyl ester}, the minimum structural unit (O1/2)3GeCH2CH2COOH, an empirical formula: C6H10Ge2 O7 as an active component. When the medical agent is administrated to a human, preferably 1-1,500 mg per day and 60-120 mg per day in a peroral administration to an adult of 50 kg weight. |
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