MCP-1 RECEPTOR ANTAGONIST CONTAINING ORGANIC GERMANIUM COMPOUND AND PREVENTIVE OR TREATING AGENT FOR ONSET OF INFLAMMATORY DISEASE OR ORGANOPATHY RELATING TO MCP-1

PROBLEM TO BE SOLVED: To obtain an MCP-1 receptor antagonist useful for inflammatory disease or organopathy relating to MCP-1 by including an organic germanium compound as an active component. SOLUTION: This MCP-1 receptor antagonist contains an organic germanium compound of formula: [(O1/2)3Ge-A-CO...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: ISHIWATARI YOSHIRO, AWATANI JUICHI, HASHIMOTO HIROYUKI, YOKOCHI SHOJI
Format: Patent
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To obtain an MCP-1 receptor antagonist useful for inflammatory disease or organopathy relating to MCP-1 by including an organic germanium compound as an active component. SOLUTION: This MCP-1 receptor antagonist contains an organic germanium compound of formula: [(O1/2)3Ge-A-CO2H]n (n)>=1; A is a lower alkyl}, preferably 3-oxygelmyl propionic acid 8-membered structural material of the formula R is -CH2CH2COOH, (m) is weight-average molecular weight of 137±84 reduced from weight-average molecular weight of propagermanium propyl ester}, the minimum structural unit (O1/2)3GeCH2CH2COOH, an empirical formula: C6H10Ge2 O7 as an active component. When the medical agent is administrated to a human, preferably 1-1,500 mg per day and 60-120 mg per day in a peroral administration to an adult of 50 kg weight.