HAPTEN COMPOUND OF ISOPROTHIOLANE, ANTIBODY AND ASSAY

PROBLEM TO BE SOLVED: To obtain a new compound useful as a hapten compound constituting an antigen for making a new monoclonal antibody reactive to isoprothiolane as a dithiolane-based rice blight-controlling agent. SOLUTION: This new compound is represented by formula I (R is a 1-5C alkyl; (n) is 1...

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Hauptverfasser:	OMODA NAIKI, FUJII ATSUSHI, HAYASHI MASAO, WATANABE SHIGEYUKI, KAMATA YOSHIO, MORIMUNE KOSUKE, KAWADA MICHIYASU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	PROBLEM TO BE SOLVED: To obtain a new compound useful as a hapten compound constituting an antigen for making a new monoclonal antibody reactive to isoprothiolane as a dithiolane-based rice blight-controlling agent. SOLUTION: This new compound is represented by formula I (R is a 1-5C alkyl; (n) is 1-15), e.g. a compound of formula II. The compound is obtained by the following steps: malonic acid is first reacted with an alcohol of the formula ROH in an organic solvent in the presence of a mineral acid or Lewis acid to effect esterification, the resulting malonic ester is then reacted with an ester compound of formula III (Z is a carboxyl-protecting group) to form the corresponding malonic diester derivative, which, in turn is reacted with carbon disulfide and a dihaloethane of the formula L1CH2CH2L2 (L1 and L2 are each a halogen) in an organic solvent in the presence of a base followed by eliminating the carboxyl-protecting group from the resulting product.