PRODUCTION OF ANILINOPYRIMIDINE DERIVATIVE AND ITS INTERMEDIATE
PROBLEM TO BE SOLVED: To obtain a new compound useful as an intermediate material for an antagonist against corticotropin-releasing factor effective against melancholia, anxiety syndrome, Alzheimer's disease, Parkinson disease, Huntington's chorea, hypertension, gastrointestinal disease, e...
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| creator | OKUBO TAKETOSHI NAKAZATO ATSUO KUMAGAI TOSHIHITO TOMIZAWA KAZUYUKI |
| description | PROBLEM TO BE SOLVED: To obtain a new compound useful as an intermediate material for an antagonist against corticotropin-releasing factor effective against melancholia, anxiety syndrome, Alzheimer's disease, Parkinson disease, Huntington's chorea, hypertension, gastrointestinal disease, epilepsy, cerebral infarction, cerebral edema or the like. SOLUTION: This new compound is a 4-tetrahydropyridino-2- alkylsulfonylpyrimidine derivative of formula I [Ar is (substituted) phenyl, thienyl or furyl where a substituted site is 4- or 5-position; R1 is H or a 1-5C alkyl; R2 is a 1-5C alkyl], e.g. 4-[4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1- yl]-2-isobutylsulfonyl-6-methylpyrimidine. The compound of formula I is obtained by reacting a compound of formula II with a tetrahydropyridine derivative of formula III. |
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SOLUTION: This new compound is a 4-tetrahydropyridino-2- alkylsulfonylpyrimidine derivative of formula I [Ar is (substituted) phenyl, thienyl or furyl where a substituted site is 4- or 5-position; R1 is H or a 1-5C alkyl; R2 is a 1-5C alkyl], e.g. 4-[4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1- yl]-2-isobutylsulfonyl-6-methylpyrimidine. 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SOLUTION: This new compound is a 4-tetrahydropyridino-2- alkylsulfonylpyrimidine derivative of formula I [Ar is (substituted) phenyl, thienyl or furyl where a substituted site is 4- or 5-position; R1 is H or a 1-5C alkyl; R2 is a 1-5C alkyl], e.g. 4-[4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1- yl]-2-isobutylsulfonyl-6-methylpyrimidine. 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SOLUTION: This new compound is a 4-tetrahydropyridino-2- alkylsulfonylpyrimidine derivative of formula I [Ar is (substituted) phenyl, thienyl or furyl where a substituted site is 4- or 5-position; R1 is H or a 1-5C alkyl; R2 is a 1-5C alkyl], e.g. 4-[4-(3-fluorophenyl)-1,2,3,6-tetrahydropyridin-1- yl]-2-isobutylsulfonyl-6-methylpyrimidine. The compound of formula I is obtained by reacting a compound of formula II with a tetrahydropyridine derivative of formula III.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PRODUCTION OF ANILINOPYRIMIDINE DERIVATIVE AND ITS INTERMEDIATE |
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