CYCLIZATION OF PENTAPEPTIDE AND HEXAPEPTIDE

CYCLIZATION OF PENTAPEPTIDE AND HEXAPEPTIDE

PROBLEM TO BE SOLVED: To provide a method for cyclizing pentapeptide and hexapeptide in high purity and in considerably high yield. SOLUTION: This cyclization method comprises using propanephosphonic anhydride (PrPO2)3 to quantitatively cyclize an open-chain pentapeptide or hexapeptide, in particula...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: PETER HENKLEIN, MOLLENKOPF CARL CHRISTOPH DR
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:PROBLEM TO BE SOLVED: To provide a method for cyclizing pentapeptide and hexapeptide in high purity and in considerably high yield. SOLUTION: This cyclization method comprises using propanephosphonic anhydride (PrPO2)3 to quantitatively cyclize an open-chain pentapeptide or hexapeptide, in particular H2N-Ile-Leu-Asp (O-tBu)-Val-NH(CH2)5-COOH or H2N-Phe-D-Trp-Ala-Thr(tBu)-Phe-Pro-COOH, into the corresponding cyclopeptide.