DERIVATI BENZ/E/INDENICI

A subject-matter of the invention are benz[e]indene derivatives of the generel formula wherein A represents a group of the formula in which latter alk means a C2-7 alkylene group, optionally substituted by a hydroxy group and R1 and R2 stand independently for hydrogen or a C1-7 alkyl, C2-7 alkenyl,...

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Hauptverfasser: SZEMEREDI KATALIN, PETOCZ LUJZA, BLASKO GABOR, SZECSEY HEGEDUS MARIA, GACSALYI ISTVAN, MEZEI TIBOR, REITER ESZER KLARA, FEKETE MARTON, GYERTYAN ISTVAN, BUDAI ZOLTAN, SZIRT KISZELLY ENIKO, GIGLER GABOR, ROHASS ZAMKOVAJA LUDMILLA, SIMIG GYULA
Format: Patent
Sprache:ita
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Zusammenfassung:A subject-matter of the invention are benz[e]indene derivatives of the generel formula wherein A represents a group of the formula in which latter alk means a C2-7 alkylene group, optionally substituted by a hydroxy group and R1 and R2 stand independently for hydrogen or a C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, mono-(C1-7)alkylamino-(C1-7)alkyl or di-(C1-7)alkylamino-(C1-7)alkyl group or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered heterocyclic ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may be substituted by a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl group which latter ones, in turn, may be substituted by a hydroxy or methoxy group or a halogen atom or a halophenyl group or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group or A means a pyrimidino group, a 2,3-(epoxy)-propyl group or a group of the formula in which latter R3 stands for a C1-7 alkyl, C2-7 alkenyl or C3-8 cycloalkyl group and R denotes hydrogen or a C1-7 alkyl group, and their stereoisomers and optically active isomers and mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds.