PROCEDIMENTO PER LA PREPARAZIONE DELLA 5-(E)-(2-BROMOVINIL)-2'--DESOSSIURI DINA E DEI SUOI DERIVATI, EDERIVATI DELLA 5-(E)-(2--BROMOVINIL)-2'-DESOSSIURI DINA

PROCEDIMENTO PER LA PREPARAZIONE DELLA 5-(E)-(2-BROMOVINIL)-2'--DESOSSIURI DINA E DEI SUOI DERIVATI, EDERIVATI DELLA 5-(E)-(2--BROMOVINIL)-2'-DESOSSIURI DINA

(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-...

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Hauptverfasser: JURGER REFSCHALAGER, ANNA SZABOLCS, LAJOS VOROSHAZY, DIETER BARWOLF, IVAN DAROCZY, JANOS SAGI, ZOLTAN RATONYI, TIBOR GAL, LASZLO OTVOS, HELGA TODOS
Format: Patent
Sprache:ita
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ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Zusammenfassung:(E)-5-(2-bromovinyl)-2'- deoxyuridine and its derivatives of general formula VI (where R is H or as defined below) are prepared from 3,5'-di-O-acyl-5-ethyl- 2'-deoxyuridines of general formula IV (wherein R is C1-8 alkanoyl, benzoyl or benzoyl group substituted in para position by C1-4 alkyl or halogen) by reaction with bromine to give a dibromo derivative of general formula V which is then dehydrohalogenated and if desired deacylated to give the compound of formula of formula (VI) in which R is H. The compounds of formula (VI) in which R is other than H are new compounds and are metabolic precursors for (E)-5-(2-bromovinyl-2'- deoxyuridine. These compounds are thus useful in medicine.