CHE LI CONTENGONO NONCHE' PROCEDI COMPOSTI ALFA-ALCHILAMMINOPROPIOFE MENTO PER LA LORO PREPARAZIONE NONICI E COMPOSIZIONI FARMACEUTICHE

CHE LI CONTENGONO NONCHE' PROCEDI COMPOSTI ALFA-ALCHILAMMINOPROPIOFE MENTO PER LA LORO PREPARAZIONE NONICI E COMPOSIZIONI FARMACEUTICHE

A method of preparing alpha-alcohol-aminopropiophenones of the formula **(See formula)** or an acid addition salt thereof, where X is chlorine or fluorine, characterized in that (a) a compound of the formula is reacted **(See formula)** where X is as defined above and B is a lower alkoxy group havin...

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1. Verfasser: NARIMAN BOMANSHAW MEHTA
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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description A method of preparing alpha-alcohol-aminopropiophenones of the formula **(See formula)** or an acid addition salt thereof, where X is chlorine or fluorine, characterized in that (a) a compound of the formula is reacted **(See formula)** where X is as defined above and B is a lower alkoxy group having 1 to 3 carbon atoms, or chlorine, bromine or iodine, with tert-butylamine, and optionally converting the product to an acid addition salt of the itself, (b) becomes a compound of the formula **(See formula)** where X is as defined above and Z is a protecting group, in a compound of formula (I) or an acid addition salt thereof; (c) a Grignard reagent of the formula is reacted **(See formula)** where X is as defined above, and Hal is halogen, with an amide or nitrile of the formula **(See formula)** where Y is a carbomoyl or cyano group, under anhydrous conditions, and the reaction product is hydrolyzed to a compound of formula (I) or an acid addition salt thereof; (d) a secondary alcohol of the formula is oxidized **(See formula)** where X is as defined above, to a compound of formula (I) or an acid addition salt thereof. (Machine-translation by Google Translate, not legally binding)
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title CHE LI CONTENGONO NONCHE' PROCEDI COMPOSTI ALFA-ALCHILAMMINOPROPIOFE MENTO PER LA LORO PREPARAZIONE NONICI E COMPOSIZIONI FARMACEUTICHE
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