CHE LI CONTENGONO NONCHE' PROCEDI COMPOSTI ALFA-ALCHILAMMINOPROPIOFE MENTO PER LA LORO PREPARAZIONE NONICI E COMPOSIZIONI FARMACEUTICHE

A method of preparing alpha-alcohol-aminopropiophenones of the formula **(See formula)** or an acid addition salt thereof, where X is chlorine or fluorine, characterized in that (a) a compound of the formula is reacted **(See formula)** where X is as defined above and B is a lower alkoxy group having 1 to 3 carbon atoms, or chlorine, bromine or iodine, with tert-butylamine, and optionally converting the product to an acid addition salt of the itself, (b) becomes a compound of the formula **(See formula)** where X is as defined above and Z is a protecting group, in a compound of formula (I) or an acid addition salt thereof; (c) a Grignard reagent of the formula is reacted **(See formula)** where X is as defined above, and Hal is halogen, with an amide or nitrile of the formula **(See formula)** where Y is a carbomoyl or cyano group, under anhydrous conditions, and the reaction product is hydrolyzed to a compound of formula (I) or an acid addition salt thereof; (d) a secondary alcohol of the formula is oxidized **(See formula)** where X is as defined above, to a compound of formula (I) or an acid addition salt thereof. (Machine-translation by Google Translate, not legally binding)