COMPOSTI IPOTENSIVI E VASODILATATO RI A BASE DI PROSTAGLANDINE PER SOMMINISTRAZIONE TOPICA O PER INIEZIONE

COMPOSTI IPOTENSIVI E VASODILATATO RI A BASE DI PROSTAGLANDINE PER SOMMINISTRAZIONE TOPICA O PER INIEZIONE

Vasodilator or hypotensive compsn. for topical appln. comprises an ointment base mixed with a prostaglandin of formula (I): (either A1 is = O, A2 is absent and A3 is ---R3 or A2+A3 form a double bond; or A1 is , A2 is absent and A3 is ---R3; R3 is H, OH or HOCH2CH2S; Z is (CH2)6, CH2CH=CH(CH2)n, (CH...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: JAY EDWARD BIRNBAUM
Format: Patent
Sprache:ita
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Vasodilator or hypotensive compsn. for topical appln. comprises an ointment base mixed with a prostaglandin of formula (I): (either A1 is = O, A2 is absent and A3 is ---R3 or A2+A3 form a double bond; or A1 is , A2 is absent and A3 is ---R3; R3 is H, OH or HOCH2CH2S; Z is (CH2)6, CH2CH=CH(CH2)n, (CH2)mSCH2 or (CH2)mOCH2; n and m are 3-5; R14 is OH, 1-6C alkoxy, CH2OH, CH2OR15 or OCation; R15 is 2-6C alkanoyl; C13-C14 is CH2CH2 or trans-CH=CH; R7 is or -CH2R9; R8 is 4-7C alkyl, cyclohexyl, cyclopentyl, -CR10-CH2 R16 is E-1-propenyl or Z-1-propenyl; R17 is 3-7C alkyl; R10 is C4h9, benzyl, CH2CHcis CHMe or CH2C triple bond Me; and R13 is Ph, PhCH2, PhO or PhO substd. by F, Cl, CF3 or Me).