CONIUGATI DI BIS-FOSFONATI CON FUNZIONALITA' ALCHILANTI AVENTI ATTIVITA' ANTITUMORALE

CONIUGATI DI BIS-FOSFONATI CON FUNZIONALITA' ALCHILANTI AVENTI ATTIVITA' ANTITUMORALE

The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CONTI MARCO, MENTA ERNESTO, SPINELLI SILVANO, D'ALO' SIMONETTA, LIVI VALERIA
Format: Patent
Sprache:ita
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents, derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.