DERIVATI BENZ/E/INDENICI FARMACEUTICAMENTE ATTIVI,PROCEDIMENTO PER LA LORO PREPARAZIONE E RELATIVE COMPOSIZIONI FARMACEUTICHE

A subject-matter of the invention are benz[e]indene derivatives of the generel formula wherein A represents a group of the formula in which latter alk means a C2-7 alkylene group, optionally substituted by a hydroxy group and R1 and R2 stand independently for hydrogen or a C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, mono-(C1-7)alkylamino-(C1-7)alkyl or di-(C1-7)alkylamino-(C1-7)alkyl group or R1 and R2 together with the nitrogen atom to which they are attached form a 4 to 7 membered heterocyclic ring, optionally comprising an oxygen atom or a further nitrogen atom, which latter may be substituted by a phenyl, benzyl, pyridyl, pyrimidinyl or C1-3 alkyl group which latter ones, in turn, may be substituted by a hydroxy or methoxy group or a halogen atom or a halophenyl group or R1 and R2 together with the nitrogen atom to which they are attached form a phthalimido group or A means a pyrimidino group, a 2,3-(epoxy)-propyl group or a group of the formula in which latter R3 stands for a C1-7 alkyl, C2-7 alkenyl or C3-8 cycloalkyl group and R denotes hydrogen or a C1-7 alkyl group, and their stereoisomers and optically active isomers and mixtures thereof, as well as acid addition salts and quaternary ammonium derivatives of these compounds. Moreover there are provided for a process for preparing these compounds, medicaments containing them and the use of these compounds.