Process for the preparation of chondroitin sulphate

The preparation of partly depolymerised and desulphated chondroitin sulphate of fish origin having a molecular weight between 10,000 and 30,000 Daltons and a sulphate/carboxyl ratio between 0.90 and 1.00 by a process which comprises treating aqueous solutions of chondroitin sulphate purified from fi...

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Hauptverfasser: ZIGGIOTTI ANTONIO, LUALDI PAOLO
Format: Patent
Sprache:eng ; ita
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Zusammenfassung:The preparation of partly depolymerised and desulphated chondroitin sulphate of fish origin having a molecular weight between 10,000 and 30,000 Daltons and a sulphate/carboxyl ratio between 0.90 and 1.00 by a process which comprises treating aqueous solutions of chondroitin sulphate purified from fish tissues having a molecular weight of 30,000 - 50,000 and a sulphate/carboxyl ratio in excess of 1.00 at a pH of 1.5 - 3 in the presence of cationic resins, followed by various purification treatments, is described. E' descritta la preparazione di condroitinisolfato di origine ittica parzialmente depolimerizzato e desolfatato, avente peso molecolare compreso fra 10.000 e 30.000 Dalton e rapporto solfati/carbossili compreso fra 0,90 e 1,00, mediante un procedimento che comprende il trattamento a pH 1,5-3 in presenza di resine cationiche di soluzioni acquose di condroitin solfato purificato da tessuti di pesce, avente peso molecolare 30.000-50.000 e rapporto solfati/carbossili superiore a 1,00, seguito da vari trattamenti di purificazione.