PROCEDIMENTO PER L'OTTENIMENTO DI UN VACCINO RICOMBINANTE CONTRO L'EPATITE B

The invention relates to an area of biotechnology. The process for the preparation of recombinant vaccines for hepatitis B comprises cultivating the producer strain of the HBsAg antigen consecutively on a nutrient medium enriched with a source of phosphorus and then on a nutrient medium which contai...

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Bibliographische Detailangaben
Hauptverfasser:	REM VIKTOROVICH PETROV, NIKOLAI NIKOLAEVICH GRANOVSKY, IGOR VIKTOROVICH KRASILNIKOV, IRINA YURIEVNA KOTKOVA, VIKTOR MIKHAILOVICH ZHDANOV, BORIS MIKHAILOVICH GIRDO
Format:	Patent
Sprache:	ita
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to an area of biotechnology. The process for the preparation of recombinant vaccines for hepatitis B comprises cultivating the producer strain of the HBsAg antigen consecutively on a nutrient medium enriched with a source of phosphorus and then on a nutrient medium which contains no sources of phosphorus, and subsequent disruption of the yeast cells and simultaneous isolation and purification of the antigen by adsorption chromatography on porous diatomaceous earth with subsequent ultracentrifugation in a density gradient from 1.1 to 1.3 kg/dm to obtain the final product. The resulting vaccines are used in medicine for prophylactic vaccination of humans against hepatitis B.