3-IDROSSIBENZODIAZEPINE

3-IDROSSIBENZODIAZEPINE

Process for the manufacture of benzodiacepine, formula (I), where r is a lower alkyl group; x is hydrogen or halogen; z is chlorine, bromo or a group of formula (II), and is a group of formula (III) or (IV). A compound of formula (V) is subjected to oxidizing substitution in glacial acetic acid, in...

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Bibliographische Detailangaben
Hauptverfasser: SUNJIC VITOMIR, KOVAC TOMISLAV
Format: Patent
Sprache:ita
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Process for the manufacture of benzodiacepine, formula (I), where r is a lower alkyl group; x is hydrogen or halogen; z is chlorine, bromo or a group of formula (II), and is a group of formula (III) or (IV). A compound of formula (V) is subjected to oxidizing substitution in glacial acetic acid, in the presence of lead tetraacetate and iodine or potassium yodide. The resultant compound is hydrolyzed in a non-aqueous mixture of cycloromethane and methanol, in the presence of an alkaline alcoxy as sodium method. The final product is purifyed by crystallization. They are used as sedatives, anticonvulsives and relaxators of the musculature. (Machine-translation by Google Translate, not legally binding)