Vaccine for animal leptospirosis

Vaccine for animal leptospirosis

Polyvalent vaccine (VGNKI) against animal leptospirosis increases immunity by contg. an antigen mixt. of VGNKI-2, -3, -4 and -6 (each of content 10-40%) or a mixt. of VGNKI-1, -4, -5 and -6 (each of content 10-40%). The proposed vaccine contains (per 1 l):leptospira antigens 100-200 mg; Al(OH)3 2.56...

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Hauptverfasser: KOSIKOV ANATOLY MIKHAILOVICH, VAKHRINA NATALYA MIKHAILOVNA, GUSCHIN VYACHESLAV NIKOLAEVICH, PANOV VASILY SERGEEVICH, SAMOKHVALOV ANATOLY PETROVICH, MALAKHOV JURY ALEXEEVICH, SCHUPLIKO ALEXANDR NAUMOVICH, DENISENKO GRIGORY FEOKTISTOVICH, ALIKHIN ROMAN MIKHAILOVICH, SOBOLEVA GALINA LEONIDOVNA, SHOROKOV ADIMIR VASILIEVICH, SEREGIN IVAN GEORGIEVICH, SOLOVIEVA VERA SERGEEVNA, PANIN ALEXANDR NIKOLAEVICH, LOGINOV IGOR ANDREEVICH
Format: Patent
Sprache:eng ; ita
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Polyvalent vaccine (VGNKI) against animal leptospirosis increases immunity by contg. an antigen mixt. of VGNKI-2, -3, -4 and -6 (each of content 10-40%) or a mixt. of VGNKI-1, -4, -5 and -6 (each of content 10-40%). The proposed vaccine contains (per 1 l):leptospira antigens 100-200 mg; Al(OH)3 2.56-28.9g; serous protein 3.5-7g; preservative 0.1-0.2g; water to 1l. As previously, the vaccine is based on the 6 VGNKI leptospira strains and contains Al(OH)3, preservative, serous protein and water. The proposed method of mer. of the vaccine involves: treating half of the vol. of leptospira culture with trichloroacetic acid (TCAA); pptg. protein and clarifying; decanting 50-70% of the clarified liq. from the acid-treated culture; mixing the remaining part (after its neutralisation) with the sepd. culture. As previously, the process involves cultivation of leptospira strain in serous media, preservation, adding TCAA